|
KMID : 0378019840270110070
|
|
New Medical Journal
1984 Volume.27 No. 11 p.70 ~ p.74
|
|
|
Intraspecific transmission of Hantaan virus, the etiologic agent of Korean Hemorrhagic fever, in Rat
|
|
|
|
|
Abstract
|
|
|
Hemorrhagic fever with renal syndrome was recognized for the first time in 1951 among U.N. troops in Korea. Since that time it has been known as Korean hemorrhagic fever (KHF) and remained endemic near the demilitarized zone between south and North Korea. In recent years it appears to have spread slowly in southwesterly direction and about 1,000 hospitalized eases are clinically diagnosed each year.
In 1976 Lee and Lee succeeded in demonstrating an antigen in lungs of the striped fieldmouse use, Apodemus agrarius, which gave specific immunofluorescent reactions with convalent sera from KHF patients for the first time.
The reservoir host of Korean hemorrhagic fever are Apodemus, Rattus and laboratory Rat in Korea. But mode of transmission of Hantaan virus in Rat is not known up to date.
This is the report on demonstration of the mode of transmission of the Hantaan virus in laboratory Rat.
1. Immunofluorescent antibody against Hantaan virus was started to appear on 17th day after inoculation of the virus, reached maximum on 4th to 5th week and declined slowly.
2. When Wistar Rat inoculated by intramuscular route, viremia appeared for about seven days beginning on 7th day.
3. Virus was recovered from lung and virus excretion in saliva and urine occurred from about 21st day through 45th day (saliva) post infection. Antigen was persisted in lung tissue for 45 days but it was not infectious virus.
4. Horizontal contact infection occurred among cage-mate to one month after infection.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|